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Gistologicheski at all kinds of herpes tap ballonirujushuju a degeneration in a false skin with formation vnutrieiidermalnyh blisters.
The herpes diagnosis establish on the basis of a clinical picture and if necessary virologic research of prints and soskobov from the centres of a lesion, smears of a separated urogenital tract. For the purpose of virus revealing use infection of cellular cultures, 12-13 day chicken embryoses, experimental animals. The subsequent identification VPG spend by means of light and a submicroscopy. Revealing of antigens VPG in biological liquids and organism cells is the direct proof active replikatsii a virus. Antigens of viruses define methods of a direct and indirect immunofluorescence with specific polyclonal or monoclonal antibodies, and also by means of an enzyme immunoassay - IFA. The newest method of revealing VPG is polimeraznaja chain reaction - Free Quit Smoking.
Treatment. At simple herpes apply antiviral preparations: atsiklovir, valtreks, famtsiklovnr. Atsiklovir prescribe inside but 200 mg of 5 times and days of 5-10 days, at the relapsing form - on 400 mg of 5 times a day or on 800 mg 2 times a day within 5 days or prescribe valtreks - inside on 500 mg 2 times a day within 5 days. The newborn with signs of primary simple herpes prescribe atsiklovir on 30 60 mg/kg/sut within 10 14 days. Aiiklovir and its analogues (zoviraks, viroleks) recommend also to pregnant women as therapeutic and a prophylactic at a neonatal infection. Treatment of relapsing simple herpes is more rational for spending in a combination to leukocytic human interferon (on a course of 3 5 injections)? 2-interferon - reaferonom, viferonom, inductors of exogenous interferon. During the interrecurrent period repeated cycles protivogerpeticheskoj vaccines which enter intradermally on 0,2 ml in 2-3 days, on a cycle of 5 injections are shown; Cycles repeat not less often than 2 times a year. At expressed suppression T of a cellular link of immunity can be prescribed immunotropnye preparations (taktivin, timoptin, Prodigiosanum, leakadin, a zymosan, kutizol, nukleinat sodium).
Naruzhno at gerpeticheskoj infections use 0,25-0,5 % bonaftonovuju: 1 % tebrofenovuju; 1 % florinalevuju; 3 % megasinovuju; 0,25-3 % oksodinovuju; 0,5-2 % tebrofenovuju; 2-5 % alpizarinovuju; 0,25-1 % riodoksolovuju ointments; 3 % Linimentum gossipola which inflict on the centre of a lesion of 4-6 times a day within 5 7 days.
Now wide application have found inaktivirovannye vaccines for intradermal injections for the purpose of preventive maintenance of relapses in disease remission.
At treatment of surrounding herpes use more often famvir on 250 mg 3 times a day within 7 days or valtreks on 0,5 g 2 times a day within 5 days; antibiotics of a wide spectrum of action: Metacyclinum, Rondomycinum, Tetracyclinum, etc. For elimination of an edema of nerves are recommended Salicylases, Diacarbum. Correction of microvascular disturbances and intravascular coagulation is carried out by Curantylum. Are used also ganglioblokatory - Gangleronum (Pachycarpinum), antiviral scale globulin, vitamins пїЅ1, пїЅ6, Acidum ascorbinicum, biogenic stimulators (Spleninum, a vitreous). From physiotherapeutic treatment the diathermy, Bernard's currents, helium the neon or infra-red laser are preferable. Naruzhno prescribe antiviral ointments, Free Quit Smoking (solkoseril, dermatolovye) agents, aniline stains.
WARTS Warts cause various types papillomavirusa the person (PVCH) and differ clinical polymorphism. Distinguish warts: vulgar (originators PVCH 2 and PVCH 3); plantar (originators PVCH 1, PVCH 2 and PVCH 4); flat (originator PVCH 3); peaked (originator PVCH 6, PVCH 11). Viruses of a papilloma of the person - DNA containing viruses; they replitsirujutsja in kernels of cells of a flat epithelium also play a part in a carcinogenesis of dermal and mucous lesions.
It is established that approximately 10 % of various forms of a cancer at men and 20 % - at women are caused papillomavirusnoj by an infection. PVCH 6 and PVCH 11 development of a cervical dysplasia and a cancer of a neck of a uterus can cause. The majority of people are not subject PVCH to an infection thanks to presence at them to antiviral resistance, in particular to a high tension of cellular immunity. At usual, plantar and flat warts the infection is transferred at direct contact to the patient through a skin at the slightest damages of a cornual layer of a false skin. At plantar warts the important contributing role is played by microtraumas of feet and the raised sweating. At peaked warts the virus is transferred by mainly sexual way.
Vulgar (usual) warts meet at any age, but more often in children's and youthful also represent giperkeratoticheskie epidermal papules in the size from 1 to 10 mm in diameter, is rare before large conglomeratic formations. Settle down usually on arms (often on fingers, round fingernails and under them). Round the basic "maternal" wart there are affiliated elements. Their outlines roundish or polygonal. Colour - corporal rozovato grayish, a surface rough. Flat warts are observed at children's and young age and breasts, a dorsum of brushes are localised on the person, a neck. They, as a rule, plural, in the form of polygonal, roundish, oval, colours of a skin with a smooth surface of papules of small size (from 1 to 3 mm), slightly tower over a skin and can linearly settle down as a result of a virus inoculation at combing. Plantar warts meet at any age in the form of individual or plural flat firm formations with rasping giperkeratoticheskoj a surface, sharply painful, especially at localisation on places of pressure in the field of a heel, a small pillow pljusnevoj bones that can complicate walking. From merge of fine warts the lesion can get a mosaic drawing. Peaked warts (sin. Peaked condylomas) - warty, fnbroepitelialnye the formations consisting of a great number of merging nodous elements with vyrostami, superficially resembling a cauliflower or a cock crest, their surface it is covered by a multilayered flat epithelium. The basis of growths is narrowed in the form of a leg, the lobular structure of condylomas is characteristic. The surrounding skin at a constant mechanical boring becomes inflamed, getting brightly red colouring. In the absence of a due care peaked condylomas matserirujutsja, papillary formations can erozirovatsja and izjazvljatsja with a purulent separated and unpleasant smell. Peaked condylomas settle down usually in places of transition of a mucosa in a skin (genitals, an urethra and rectum mucosa, perianal area, an oral cavity mucosa, a conjunctiva). The virus is transferred by mainly sexual way. Factors contributing to disease the maceration of a skin, allocation from an urethra and a vagina serve at a gonorrhea, trihomoniaze and other genitourinary infections, bad hygienic care analnogenitalnoj as area.
Peaked condylomas can remind flat condylomas at a secondary recurrent syphilis. The last have medno red colour, wide infiltrirovannoe the basis, at them is absent dolchatost. In separated flat condylomas in a considerable quantity are found out acyanotic treponemy. Huge Quit Smoking peaked warts should be differentiated also with a skin cancer.
Treatment of warts is carried out by several groups of methods: destructive - physical (surgical excising, electrosurgical, krio - and laserotherapy) and chemical (nitric and trihloruksusnaja acids, Pheresolum, kondilin, solkoderm); use tsitogoksncheskph preparations (at anogenitalnyh lesions) - podofillnn, a podophyllotoxin, 5 ftoruratsil; immune preparations - an alpha, beta- both scale of interferons and the combined methods. Efficiency of various methods fluctuates from 50 to 94 %. Main principles of treatment VPCH are based on destruction of the centres of a lesion by one of the named ways with the subsequent immunostimulirujushej therapy. Regarding wart cases are completely resolved spontaneously. At plantar warts drawing of cauterising and blasting substances is preceded usually by the procedures softening their surface and promoting penetration of used preparations (mylno soda trays, Acidum salicylicum applications). After keratolytic effect a blanket of warts take out and put on them one of medical solutions. During treatment to reduction of pressure and pains at walking apply the rubber rings fixed round warts by an adhesive plaster. The good effect is reached at weekly processings of warts anogenitalnoj areas of 10-25 % by Podophyllinum solution (during 3-5 ned). Through 4 ch after processing it is necessary to wash the processed centre or to make a sedentary bath. At peaked warts use applications kondilina (Free Quit Smoking) twice a day 3 day cycles with 4 day breaks (to 6 cycles of treatment). Treatment of flat warts from for their large number is complicated and from cosmetic reasons should not be injuring. Long application applications of 30 % of a solution trihlouksusnoj acids or 5 % of ointment ammonijnoj can give once a week to mercury good effect. Treatment of vulgar warts on brushes and stops the carbonic laser (1-3 sessions), plantar warts - a method of a sparing cryolysis is effective at processing by liquid nitrogen as rigid kriomassazha during 20-30 with for a session. Repeated procedures spend in 2-4 days. At the expressed hyperkeratosis before each procedure on 12-24 ch on the centre impose an adhesive plaster of "Salipod" and directly ahead of cryotherapy do mylno a soda foot tray. At treatment of usual warts use solkoderm, containing ions of metals and nitrites and rendering destructive, mummificating effect. It inflict on the surface of the centre of a lesion degreased by alcohol by means of a glass capillary or a plastic spatula. Usually spend 2-4 sessions with 4-5 day interval for the full permission of rashes. The total disappearance of usual and plantar warts is reached unitary obkalyvaniem by their Pyrogenalum in a dose of 2,5 mkg on 1 ml of an isotonic solution of Sodium chloridum. Are useful at papillomavirusnyh lesions interferons and their inductors. They, strengthening cytotoxic activity T of lymphocytes, raise their ability to blast a cell with the changed structure. Human leukocytic interferon is entered on 500 thousand ME by 1-2 times a week, on a course of 10 injections.
WARTS Warts cause various types papillomavirusa the person (PVCH) and differ clinical polymorphism. Distinguish warts: vulgar (originators PVCH 2 and PVCH 3); plantar (originators PVCH 1, PVCH 2 and PVCH 4); flat (originator PVCH 3); peaked (originator PVCH 6, PVCH 11). Viruses of a papilloma of the person - DNA containing viruses; they replitsirujutsja in kernels of cells of a flat epithelium also play a part in a carcinogenesis of dermal and mucous lesions.
It is established that approximately 10 % of various forms of a cancer at men and 20 % - at women are caused papillomavirusnoj by an infection. PVCH 6 and PVCH 11 development of a cervical dysplasia and a cancer of a neck of a uterus can cause. The majority of people are not subject PVCH to an infection thanks to presence at them to antiviral resistance, in particular to a high tension of cellular immunity. At usual, plantar and flat warts the infection is transferred at direct contact to the patient through a skin at the slightest damages of a cornual layer of a false skin. At plantar warts the important contributing role is played by microtraumas of feet and the raised sweating. At peaked warts the virus is transferred by mainly sexual way.
Vulgar (usual) warts meet at any age, but more often in children's and youthful also represent giperkeratoticheskie epidermal papules in the size from 1 to 10 mm in diameter, is rare before large conglomeratic formations. Settle down usually on arms (often on fingers, round fingernails and under them). Round the basic "maternal" wart there are affiliated elements. Their outlines roundish or polygonal. Colour - corporal rozovato grayish, a surface rough. Flat warts are observed at children's and young age and breasts, a dorsum of brushes are localised on the person, a neck. They, as a rule, plural, in the form of polygonal, roundish, oval, colours of a skin with a smooth surface of papules of small size (from 1 to 3 mm), slightly tower over a skin and can linearly settle down as a result of a virus inoculation at combing. Plantar warts meet at any age in the form of individual or plural flat firm formations with rasping giperkeratoticheskoj a surface, sharply painful, especially at localisation on places of pressure in the field of a heel, a small pillow pljusnevoj bones that can complicate walking. From merge of fine warts the lesion can get a mosaic drawing. Peaked warts (sin. Peaked condylomas) - warty, fnbroepitelialnye the formations consisting of a great number of merging nodous elements with vyrostami, superficially resembling a cauliflower or a cock crest, their surface it is covered by a multilayered flat epithelium. The basis of growths is narrowed in the form of a leg, the lobular structure of condylomas is characteristic. The surrounding skin at a constant mechanical boring becomes inflamed, getting brightly red colouring. In the absence of a due care peaked condylomas matserirujutsja, papillary formations can erozirovatsja and izjazvljatsja with a purulent separated and unpleasant smell. Peaked condylomas settle down usually in places of transition of a mucosa in a skin (genitals, an urethra and rectum mucosa, perianal area, an oral cavity mucosa, a conjunctiva). The virus is transferred by mainly sexual way. Factors contributing to disease the maceration of a skin, allocation from an urethra and a vagina serve at a gonorrhea, trihomoniaze and other genitourinary infections, bad hygienic care analnogenitalnoj as area.
Peaked condylomas can remind flat condylomas at a secondary recurrent syphilis. The last have medno red colour, wide infiltrirovannoe the basis, at them is absent dolchatost. In separated flat condylomas in a considerable quantity are found out acyanotic treponemy. Huge Quit Smoking peaked warts should be differentiated also with a skin cancer.
Treatment of warts is carried out by several groups of methods: destructive - physical (surgical excising, electrosurgical, krio - and laserotherapy) and chemical (nitric and trihloruksusnaja acids, Pheresolum, kondilin, solkoderm); use tsitogoksncheskph preparations (at anogenitalnyh lesions) - podofillnn, a podophyllotoxin, 5 ftoruratsil; immune preparations - an alpha, beta- both scale of interferons and the combined methods. Efficiency of various methods fluctuates from 50 to 94 %. Main principles of treatment VPCH are based on destruction of the centres of a lesion by one of the named ways with the subsequent immunostimulirujushej therapy. Regarding wart cases are completely resolved spontaneously. At plantar warts drawing of cauterising and blasting substances is preceded usually by the procedures softening their surface and promoting penetration of used preparations (mylno soda trays, Acidum salicylicum applications). After keratolytic effect a blanket of warts take out and put on them one of medical solutions. During treatment to reduction of pressure and pains at walking apply the rubber rings fixed round warts by an adhesive plaster. The good effect is reached at weekly processings of warts anogenitalnoj areas of 10-25 % by Podophyllinum solution (during 3-5 ned). Through 4 ch after processing it is necessary to wash the processed centre or to make a sedentary bath. At peaked warts use applications kondilina (Free Quit Smoking) twice a day 3 day cycles with 4 day breaks (to 6 cycles of treatment). Treatment of flat warts from for their large number is complicated and from cosmetic reasons should not be injuring. Long application applications of 30 % of a solution trihlouksusnoj acids or 5 % of ointment ammonijnoj can give once a week to mercury good effect. Treatment of vulgar warts on brushes and stops the carbonic laser (1-3 sessions), plantar warts - a method of a sparing cryolysis is effective at processing by liquid nitrogen as rigid kriomassazha during 20-30 with for a session. Repeated procedures spend in 2-4 days. At the expressed hyperkeratosis before each procedure on 12-24 ch on the centre impose an adhesive plaster of "Salipod" and directly ahead of cryotherapy do mylno a soda foot tray. At treatment of usual warts use solkoderm, containing ions of metals and nitrites and rendering destructive, mummificating effect. It inflict on the surface of the centre of a lesion degreased by alcohol by means of a glass capillary or a plastic spatula. Usually spend 2-4 sessions with 4-5 day interval for the full permission of rashes. The total disappearance of usual and plantar warts is reached unitary obkalyvaniem by their Pyrogenalum in a dose of 2,5 mkg on 1 ml of an isotonic solution of Sodium chloridum. Are useful at papillomavirusnyh lesions interferons and their inductors. They, strengthening cytotoxic activity T of lymphocytes, raise their ability to blast a cell with the changed structure. Human leukocytic interferon is entered on 500 thousand ME by 1-2 times a week, on a course of 10 injections.